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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers
doi: 10.3390/ijms21082770
Figure Lengend Snippet: Tamsulosin is metabolized to five known metabolites by cytochrome P450 enzymes, mainly CYP3A4/5 and CYP2D6. After oral administration, M-1 is the major product (15.7% of the dose), followed by AM-1 (7.5% of the dose) and M-3 (6.4% of the dose). The formation of tamsulosin metabolites M-1 and AM-1 is mainly catalyzed by CYP3A isoforms (CYP3A4/5). The formation of M-3 is mainly catalyzed by CYP2D6 [ , ].
Article Snippet: We used the CYP2C9 and CYP2C19 Mutation Detection Kits (Roche Diagnostics, Mannheim, Germany), and CYP3A4 and
Techniques:
Journal: International Journal of Molecular Sciences
Article Title: Tamsulosin Associated with Interstitial Lung Damage in CYP2D6 Variant Alleles Carriers
doi: 10.3390/ijms21082770
Figure Lengend Snippet: Characteristics of the 22 patients with suspected tamsulosin-induced ILD. Abbreviations: NSIP = non-specific interstitial pneumonia; IPF = idiopathic pulmonary fibrosis; AS = activity score (range between AS = 0 (poor metabolizer) and AS > 2 (ultra-rapid metabolizer)); n/a = not available; PM = poor metabolizer; IM = intermediate metabolizer.
Article Snippet: We used the CYP2C9 and CYP2C19 Mutation Detection Kits (Roche Diagnostics, Mannheim, Germany), and CYP3A4 and
Techniques: Activity Assay